The CHARTER Study accomplishes its Scientific Aims with direction from a Coordinating Center at the University of California, Diego and six national research sites.
CHARTER COORDINATING CENTER SERVICE COMPONENTS
- Administrative Component PI: Igor Grant, MD
- CHARTER Resource CoI: Thomas Marcotte, PhD
- Statistics Component PI: Ian Abramson, PhD
- Data Management and Information Systems Component PI: Anthony Gamst, PhD
The CHARTER Service Components oversee the scientific direction and infrastructural support that are essential to the fulfillment of the aims of the individual Components, Sites, and the CHARTER project as a whole. This includes protocol implementation and tracking, database provision and management, and statistical support in the assessment of CHARTER aims.
CLINICAL COMPONENTS (click core name for more information)
- Neuromedical Component PI: Ron Ellis, MD, PhD
The Neuromedical Component is responsible for characterizing participants clinically (neurological diagnoses, antiretroviral treatments), collecting samples including cerebrospinal fluid, and stages participants with respect to the 1993 CDC HIV disease classification system.
- Neurobehavioral Component PI: Robert Heaton, PhD
The Neurobehavioral Component provides characterization of neurocognitive deficits and their functional impact in HIV-infected persons in the era of HAART.
- Neuroimaging Component PI: Christine Fennema-Notestine, PhD
The Neuroimaging Component coordinates image analysis and hypothesis testing focused on magnetic resonance imaging (MRI) indicators of brain injury secondary to HIV, and the effects of antiretroviral (ARV) treatments.
- Laboratory & Virology Component CoIs: Scott Letendre, MD; Davey M. Smith, MD
The Laboratory & Virology Component is responsible for the processing and storage of all biological samples obtained during course of the study along with the provision genotypic resistance data for paired CSF and blood samples.